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holland plastic surgery & Aesthetics is the 1st and ONLY

pellet insertion site in Maine!

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Meet Charlene, C.

Meet our patient Charlene. Around here we call her the Grandmother of BioTE. She is the one who encouraged Dr. Holland to research BioTE Bio-identical Hormone Therapy after experiencing the life changing effects first hand. Because of Charlene, we are helping our community not only feel better, but also adding an extra layer of protection for hearts, breasts, brains and bones. We’re so thankful for Charlene’s compassion and desire to pay it forward!


hormone pellet therapy for women

Bio-identical hormone replacement therapy using the pellet method has changed the manner in which women age. In the past, women died more frequently in childbirth, PMS was an imaginary problem, and menopause, with all of its age-related infirmities, was just another stage of life to be endured and lived with. Today, we know that we don't have to accept hormonal imbalance as a grim reality. The BioTE Method is a quality, multi-faceted approach to changing healthcare and helping patients achieve a state of optimal health and well-being.


Estrogen Pellet Therapy

  • Estrogen helps regulate menstrual cycle before menopause

  • Essential for reproduction (females AND males)

  • Regulates processes in brain, nervous system, bones, liver, urinary tract, vagina and even GI tract

  • Stimulates breast growth in puberty & development of secondary sex characteristics (curves)

  • Made mostly in ovary (females)

  • Also made in adipose tissue (males & females) via aromatization

  • Decreased estrogen results in: Hot flashes, anxiety, vaginal dryness, mood swings, atherosclerosis, headaches/migraines, vaginal infections, joint pain, dry skin, bloating, depression and memory lapses

Testosterone Pellet Therapy

  • Testosterone is made in the ovaries and testes

  • Women lose HALF of testosterone production by age 40

  • Low testosterone in women can result in: Increased risk for Alzheimer’s Disease, increased risk for cardiovascular disease, and possibly increased risk for breast cancer

  • Benefits of testosterone in women include: Enhanced libido, improved cholesterol, increased energy, enhanced sleep, breast protection, increased lean body weight, stronger bones and muscles, reduced “brain fog”, improved cognition, and caridovascular/heart production


What is BHRT pellet therapy?

What are the many benefits of pellet therapy to women? BioTE® Medical offers wellness in the form of pellet therapy. The path to feeling better begins with exploring the benefits of pellet therapy. Bio-identical hormone replacement therapy or BHRT is the most natural way to overcome hormone deficiencies and hormone imbalances at any age. Bio-identical hormones have many benefits over conjugated hormones. These hormones are delivered to patients in the form of pellets. These pellets are placed just under the skin in an outpatient procedure with less than a week of recovery time before patients can return to their normal active lifestyles and exercise routines.


what are the benefits to BHRT pellets?

  • The hormones within BHRT pellets are bio-identical, meaning that they are structurally the same as naturally occurring human hormones

  • These hormones are found in nature and are plant derived. This implies that the hormones used in BHRT pellet therapy for women are more natural and may have fewer negative interactions within the body

  • Dosing is tailored to the individual patient

  • Absorbed based on cardiac output, which mimics the body’s production of hormones

  • Less roller coaster effect, resulting in less mood swings

what are pellets?

  • Pellets contain bio-identical hormones custom compounded in a pharmacy within the United States

  • The quality of the hormones used for BioTE Medical pellets is extremely high and consistently tested in every batch

  • Must comply with CGMP (Current Good Manufacturing Practice) requirements

  • Are inspected by FDA according to a risk-based schedule



Hormones Protect… Brain, Bones, Heart and Breast

  • Dementia takes 15-20 years to develop and begins with Mild Cognitive Impairment

  • MCI begins in the 30s-40s

  • By 80-85, 50% of Americans have dementia

  • Dementia may be accelerate by hormonal and neurotransmitter imbalances

  • Bioidentical hormones increase cerebral blood flow, decrease inflammation, decrease the unhealthy proteins seen in Alcheimer’s, estradoil has better effects on verbal memory and testosterone improves cognition & memory

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  • Approximately 1 in 7 women over the age of 50 has osteoporosis

  • Approximately 4% of muscle mass is lost during the first 3 years of menopause

  • Testosterone increases lean body mass & decreases fat mass

  • Pellets have 8.3% increase per year in bone density


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  • Leading cause of morbidity and mortality in the United States

  • Affects 12 million people with 1 million deaths per year

  • 1 in 7 premenopausal women die from heart disease and for postmenopausal women, that number rises to 1 in 3

  • Pellets increase blood flow, decrease inflammation, improve insulin resistance, reduce body fat, and improves HDL (with no adverse effect on platelets)

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  • Breast cancer is the most common female cancer with a median age of 61 years old

  • 400,000 deaths annually worldwide and 75% occur in postmenopausal women

  • 80% are hormone receptor positive and NO studies show that estrogen causes cancer

  • Breast cancer survivors can be treated with testosterone and/or testosterone with anastrozole


why does delivery matter?

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Learn More About Bioidentical Hormone Therapy Here:

biote faq


Q. Are pellets FDA approved?

A. The estradiol and testosterone in the BioTE pellet are FDA approved, but the actual pellet is not.

Q. What should I do before the procedure?

A. One week before the procedure, if possible, stop all NSAIDs (aspirin, ibuprofen, acetaminophen, naproxen sodium, etc.). No fasting in advance of the procedure is required.

Q. What test is required before the insertion?

A. BioTE requires, at the minimum, our comprehensive blood panel which can be discussed with your BioTE provider.

Q. Do patients need to stop taking any medications before getting labs drawn?

A. If you are currently on creams, patches or oral HRT, you should not apply or take your hormones directly before getting your blood drawn. Once blood is drawn, patients may resume taking or applying as directed. For injectable hormones, BioTE recommends drawing blood the day they are supposed to receive their not shot before they receive their hormones. Once pelleted, women will stay on their existing estrogen hormone therapy for 3 days and then discontinue on day 4.

Q. How big are the pellets and can you feel them?

A. They are about the size of a large grain of rice. Occasionally pellets may be felt underneath the skin. Sometimes the area is more palpable due to swelling. Limit gluteal exercies after insertion can reduce this swelling.

Q. What happens during the in-office insertion?

A. During the in-office visit, which only takes a few minutes, patients are brought into the exam room, and the insertion site is numbed. The most common site of insertion is the upper buttocks. A small incision is then made for the pellet to be inserted. Once the pellet is inserted, the insertion site is covered with a small bandage. You will return 6 weeks after the initial insertion for a follow up blood panel to determine any dosing changes.

Q. Do I need to take supplements in addition to my BioTE pellets?

A. YES. Nutraceutical supplements will be recommended to you by Dr. Holland at your consultation and can be purchased in our office. Supplements are key in providing integrated wellness in the areas of healthy hormone balance, disease prevention and supplementing diets.

Q. What happens during the week following the insertion?

A. After pellet insertion, its best to eliminate lower body exercise. This doesn’t include walking, but, extraneous exercise is not recommended. Swimming, hot tubs, and bath tubs are to be avoided, this doesn’t include showers. After removal of the bandage, normal activities may resume.

Q. How often is pellet insertion necessary?

A. Each patient’s symptoms are unique and each patient’s paths to optimization is unique. Your journey will be specialized to fit your specific needs. Just as it doesn’t take you 1-2 weeks to get out of balance, it doesn't resolve that quickly either.

Q. What happens to pellets after insertion?

A. Since the pellets are bio-identical and contain nothing other than the hormone your body naturally produces, the pellets are completely dissolved and absorbed, leaving nothing behind.

Q. How often do you need pellets?

A. For women 3-6 months depending on age, activity and stress level. Most women however have symptom relief around 3 to 4 months on average.

Q. What about patients on birth control?

A. Stay on your birth control. Pellets do no serve as a method of contraception.

Q. Are there side effects to pellet therapy?

A. Less than 2% of patients experience actual side effects. Side effects or secondary responses are minimal and very easily managed. Some reported responses are noticeable in the first two rounds during the initial balancing phase. These include: fluid retention, post-menopausal bleeding, acne and hair growth or thinning.

Q. How long will it take for body changes to occur?

A. An exercise regime & healthy diet is essential in optimizing hormones. Body changes are typically seen with the 2nd and 3rd insertions, typically 4-6 months after initiating therapy.